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GLP 1 medications like Ozempic and Wegovy work by mimicking a natural hormone that regulates appetite and blood sugar. They signal your brain that you're full sooner, slow down how quickly your stomach University Gastroenterology is leading research and helping shape the future of digestive care through clinical trial studies involving GLP 1 medications for digestive conditions including fatty Approved 20 years ago as a treatment for diabetes, GLP 1 drugs have been found also to help patients significantly reduce weight. More than 30 million people in the U.S. have had their lives changed What happens when you stop taking a GLP 1 medication? In a large Cleveland Clinic study, many patients maintained or continued weight loss. It shows why ongoing support matters. Learn more: https: cle.clinic 4rQEehW Amazon.com: GLP 1 Supplement 15 in 1 Complex,GLP1 for Weight Loss GLP 1 Probiotic Powder for Control Appetite and Cravings,Appetite Suppressant,Metabolism Booster 30 Serving Packets : Health & Household
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Best in 7 days
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4.4 ★★★★★
Based on 1500 reviews
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Product Reviews
★★★★★ 5
Actually Holds up
Color: Knuckle Bone, Size: XX-Large
I must say I had low expectations when buying this bone based on prior experience of similar products. I'm happy to say I was pleasantly surprised. I bought this bone off Amazon in the beginning of December, I wanted to wait a while for my review to see if it would actually hold up. So far so good. There are several factors that set this bone above similar products.
First let me be clear that this is the Beef bone not the chicken etc. (I'm told there is a huge difference)
1. The first thing that impressed me is that my dog actually loves to chew on it. I know this may sound weird but I tried the puppy pack of nylabones and a bit larger one. He was interested in them but it didn't last and he wouldn't touch them anymore. This bone on the other hand is his absolute favorite. He carries it around everywhere. Even though it's beef flavored it doesn't have a noticeable smell or residue and it doesn't get slimly like a real bone.
2. This bone is extremely durable. I have a chew happy 10 month old lab puppy with razor teeth and majoring chewing skills. Trust me, my ruined shoes are proof :) It's been almost two months and I can just see where the bone has worn down. The down side to this is it is extremely heavy, not ideal to be leave around to step on, especially because of the way the bone breaks down. As they chew on it is almost peals away into tiny, tiny chunks. This is great compared to a kong stick that he had where he was swallowing large pieces of a rubber/plastic material. The downside is that as it "peals" it leaves the bone very sharp, with little spikes around where they chew. So far my dog doesn't seem to mind and it doesn't seem to make his mouth bleed or anything so that's a minor negative. Just don't stub your toe on it! Trust me!
Overall after trying multiple brand/types and flavors this is the only one that gets my seal of approval.
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Reviewed in the United States on January 29, 2012
★★★★★ 5
This is a great option for tough chewers
Color: Knuckle Bone, Size: XX-Large
This is a great option for tough chewers, although if your dogs are anything like ours, there is a procedure to ANY new toy no matter how "tough". If I gave them this Nylabone and they went unsupervised day one, they would wreck it and it'd be in the trash within the hour. I say this to tell you, if you have a top 10 bite strength aggressive chewer, that you shouldn't expect a miracle.
If instead, I give it, take it away when they are working it too hard or being particularly destructive, and then give it back- and do this a few times for a week or so, then they'll chew it in a less aggressive fashion- they'll enjoy it and it lasts a long time. I don't know what it is about the first few days, but when something is "new" it has to be destroyed.
When it's been in the house a few days, they are rough but not as bad. Like the ones listed "virtually indestructible" will last 6 months as long as we have multiple around. It will show damage, there will be shrapnel in the carpet that will scratch up your feet, but it'll be worthy of play still. I consider 6 months in our house worthy of 5 stars.
This has been true for 2 Dobermans and a German Shepherd- and all of them have proven ability to destroy these products day 1 if I don't behave appropriately on introducing the new toy. If your dog wrecks these in the first 10 minutes, I'd say you probably need to work on supervising new toy play, and taking it away when they become to aggressive. This is a training issue, it can be done!
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Reviewed in the United States on December 27, 2015
★★★★★ 5
Lasting longer than 6 months, longer than any bone to date.
Color: Mega Knot Bone, Size: X-Large
Finally a bone that has lasted longer than 6 moths so far. I know my dog is a chewer. Well worth the cost to not have to replace them as often.
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Reviewed in the United States on November 20, 2025
★★★★★ 5
Great quality
Color: Knuckle Bone, Size: XX-Large
Great quality. Our puppy is having a great time and it's holding up perfectly.
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Reviewed in the United States on November 9, 2025
★★★★★ 5
Do away with vet teeth cleaning. Great product.
Color: Monster Bone, Size: XX-Large
My large dogs love these. It keeps their teeth clean and no tarter or cavities after 4 years of using. It has even helped an adopted older dog to have stronger teeth. They don't ingest anything, so safe to chew on.
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Reviewed in the United States on October 18, 2025
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