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Can a doctor or biologist explain why GLP 1 use leads to increased heart rate? Is this a neurological effect? I came across this in the Retatrutide Phase II data appendix. At the highest Nutritional Care for Adults With Obesity Treated With Glucagon Like Peptide (GLP) 1 and Dual Glucose Dependent Insulinotropic Polypeptide (GIP) GLP 1 Receptor Agonists: A Review of Evidence, Gaps, and Clinical Implications Cureus Medical Aid Cover For Ozempic And Weight Management (2026*) Discontinuing GLP 1s before or early during pregnancy raises risk for complications Wegovy Pill and Wegovy Pen Now Available with Hims & Hers
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Best in 7 days
Best in 7 days
Best in 7 days
Best in 7 days
4.6 ★★★★★
Based on 1167 reviews
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Product Reviews
★★★★★ 3
Way too narrow
Size: 9.5 Wide, Color: Burgundy Polished Full Grain
I ordered a wide in this shoe, but it was still way too narrow. I had to return them. Otherwise, it looked like a nice quality shoe.
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Reviewed in the United States on February 12, 2026
★★★★★ 5
I usually wear 11.5's, but I buy 1/2 size smaller to accommodate for stretch. Leather relaxes.
Size: 11, Color: Burgundy Polished Full Grain
5 STARS: These shoes are awesome. I keep coming back for more. I have major foot problems, have tried all kinds of shoes, orthotics, and inserts... but believe it or not, these shoes work better than any of that stuff. I wear them daily. I buy lots of them, for home, for church, and I'm getting my first pair of J&M boots today, for winters in Indiana... Brrrr
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Reviewed in the United States on December 18, 2025
★★★★★ 5
Great price great shoe
Size: 12, Color: Burgundy Polished Full Grain
Excellent shoe. Tried the Sebago penny loafer and the sizing was ridiculous. These J and M are sized perfectly. I’ve had them before and they wear like iron. Very comfortable right out of the box.
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Reviewed in the United States on May 23, 2026
★★★★★ 5
One of the best shoes
Size: 9.5, Color: Black Polished Full Grain
Outstanding. Fashionable, most comfortable and good construction. No sines of use after quite some time. Highly recommended.
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Reviewed in the United States on March 21, 2026
★★★★★ 4
Quality shoe but with a slight squeak.
Size: 10 Wide, Color: Burgundy Polished Full Grain
Nice shoes with the classic Penny Loafer design. Fit was better than another brand I tried. Only reason not 5 starts is disappointment due to a slight squeak at times when walking.
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Reviewed in the United States on August 11, 2025
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