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GIPR GLP 1R dual agonist therapies for diabetes and weight losschemistry, physiology, and clinical applications: Cell Metabolism The push to make weight loss drugs more affordable is running into legal limits. Telehealth company Hims & Hers pulled a less expensive oral version of Wegovy after lawsuits from Novo Nordisk and Semaglutide lowers blood pressure via GLP 1 receptors on vascular smooth muscle, not via endothelial or immune pathways. There is a direct vasorelaxant mechanism linking GLP 1R activation to BP and Scott Isaacs, What Reddit's GLP 1 Communities Are Saying About Food The Sustained Effects of a Dual GIP GLP 1 Receptor Agonist, NNC0090 2746, in Patients with Type 2 Diabetes: Cell Metabolism
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Best in 7 days
Best in 7 days
Best in 7 days
Best in 7 days
4.8 ★★★★★
Based on 668 reviews
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Product Reviews
★★★★★ 5
Worked perfectly for me. Sorry I waited so long.
Size: 1 Gallon + Tool, Set name: Off-Road Formula
I was clearing a field full of mesquite trees, and my tractor tires were getting destroyed. Mesquite has nasty 3-inch thorns, and I was plugging tires constantly. Eventually, all four tires were flat at the start of each day. These tires had been plugged more than 10 times each.
I bought FlatOut Quick Strike and followed the instructions exactly. The pump dispenses about 1 oz per pump, so I put 30 pumps in each tire, and the bottle was mostly empty by the time I finished. Typical with any pump dispenser it was also difficult to get the last bit out of the bottle using the pump.
It’s been a week now. One tire has lost about 1 PSI, but the other three are still holding exactly where I set them.
Considering how badly these tires were damaged, I’m impressed so far. This is the first time I’ve gone more than a day without dealing with flats in that field.
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Reviewed in the United States on February 13, 2026
★★★★★ 4
Pump is worthless
Size: 1 Gallon + Tool, Set name: Small Tire/Bicycle Formula
The sealant is good. The gallon pump is a joke. Pump stopped working 4 pumps in. Went and got another replacement pump from automotive store, also broke after 4 pumps. Ended up cleaning out an old Slime bottle and pouring in the flat out sealant in the slime bottle, so I could actually get it in my tires.
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Reviewed in the United States on May 30, 2026
★★★★★ 1
There seems to be a chronic problem with the provided dispensing pump.
Size: 1 Gallon + Tool, Set name: Off-Road Formula
I looked at online reviews of the product performance and was impressed by its purported ability seal tire punctures. While the product may (or may not) perform well, the provided dispensing pump is pathetically unsuited for the application and it is impossible to clear the pump once the material clogs the small dispensing port. Some of the reviews indicated this but i assumed that they were not very mechanical inclined customers. The product, by design, has particulates, of varying sizes, suspended in the liquid sealant. The port on pump is very small and easily becomes blocked with the sealant and particulates that cannot be cleared; even when following the instructions to do so. It is very irresponsible for the manufacturer to continue selling this item with inevitable relative failure of the pump as this is the only way to get the sealant into a tire.
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Reviewed in the United States on January 2, 2025
★★★★★ 5
Good for ebike tires
Size: 1 Gallon + Tool, Set name: Small Tire/Bicycle Formula
Got it for my son’s older ebike that my wife rides now. He kept on popping tubes, maybe because of his weight. Anyhow, I fixed it up for my wife and put some FlatOut in it to prevent flats. Seems to work so far. Got the off road FlatOut for my ebike’s fat tires. Easy to add to the tires. The pump clogs up but it’s easy to clean. I will always add this to all tires moving forward!
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Reviewed in the United States on April 4, 2026
★★★★★ 5
Easy to use and works great
Size: 1 Gallon + Tool, Set name: Off-Road Formula
Easy to use
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Reviewed in the United States on April 22, 2026
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